Genetika člověka
Mikrobiologické aplikace
NGS
Rapid testy
PCR plasty
Pipetovací špičky
Plasty pro buněčnou kultivaci
Systém pro dlouhodobé skladování vzorků
Zkumavky
Třepačky
Suché lázně
Centrifugy
End Point cyclery
Real-time PCR cyclery
Fluorometry
Spektrofotometry
Izolátory nukleových kyselin
Pipetovací roboty
Biobanking
Live Cell Imaging
Jednokanálové
Multikanálové
Sérologické pipety
Jednorázové pipety
Buněčné kultury
PCR, qPCR, RT
Detekce Mycoplasmat
Reverzní transkripce
Alergie
Intolerance
Elisa
Imunologické analyzátory
Veterinární imunologie
Alergie u zvířat
Intolerance u zvířat
Biochemie
Imunoanalýza
MuCaP321 Cells
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Tumor Cells |
| Tissue Type |
Prostate |
| Organism |
Mouse (M. musculus) |
| Donor History |
Mouse prostate cancer ,PSA-Cre;PtenLoxP/LoxP genetic engineered mouse model (GEMM) |
| Growth Properties |
Adherent ,epithelial |
| Growth Conditions |
PriCoat™ ECM T25 Flasks (G999) or Applied Cell Extracellular Matrix (G422) are required for cell adhesion to the culture vessels. PriGrow II (TM002) + 10% FBS + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method |
Tumor Cell Line |
| Full Information |
MuCaP321 is an epithelial prostate cancer cell line derived from a PSA-Cre targeted Pten knockout (KO) primary prostate tumor in FVB mice. This cell line exhibits a fast growth rate and forms syngeneic tumors in immunocompetent mice within 1-2 months. Histologically, MuCaP321 syngraft tumors predominantly display a sarcomatoid carcinoma growth pattern with low CK8 expression. This cell line is characterized by constitutive activation of the PI3K/Akt pathway, as indicated by elevated levels of phosphorylated Akt and its downstream targets. The cells proliferates very rapidly into tumors after subcutaneous injection.MuCaP321 is useful for studying the aggressive, undifferentiated aspects of prostate cancer and the tumor microenvironment’s immune cell composition, particularly the low presence of CD3+ T-cells.Additional cell lines from the MuCaP model:Cat. T8302 – MuCaP376 CellsCat. T8303 – MuCaP379AP CellsCat. T8304 – MuCaP379.1 Cells
