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Imunoanalýza
Immortalized Adult Mouse Ventral Prostate Cells (INK4 -/- VP)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Prostate |
| Organism |
Mouse (M. musculus) |
| Donor History |
INK4a mouse |
| Growth Properties |
Adherent ,fibroblast-like |
| Growth Conditions | |
| Immortalization Method |
Isolated from p16INK4a and p19ARF Knockout Transgenic Mice |
| Full Information |
https://www.abmgood.com/immortalized-adult-mouse-ventral-prostate-cells-ink4-vp.html |
The Immortalized Adult Mouse Ventral Prostate Cells (INK4 -/- VP) were derived from a subline of the INK4a mouse, a transgenic knockout that lacks p16INK4a and p19ARF. Both p16INK4a and p19ARF are specific inhibitors of cyclin-dependent kinases Cdk4 and Cdk6 that regulate cell cycle progression. The cells were isolated from the ventral prostate (VP), which is lined by columnar epithelium that exhibits focal folding. The luminal secretory cells in the epithelium produce homogenous slightly basophilic secretion into the lumen of the ventral prostate. This cell line is a useful model for studying the prostate storma-epithelium signalling way, which plays an important role in prostate development and cancer progression.
