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Imunoanalýza
APOA1 Expressing HepG2 Stable Cell Line (HepG2-WT-ApoA1)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Stable (KO/Expressing) Cells |
| Tissue Type |
Liver |
| Organism |
Human (H. sapiens) |
| Donor History |
Male ,15 ,White ,Hepatocellular carcinoma |
| Growth Properties |
Adherent ,epithelial-like |
| Growth Conditions |
PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. Dulbecco's Modified Eagle Medium (DMEM) ,High Glucose (TM500) + 10% FBS + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method | |
| Full Information |
The APOA1 Expressing HepG2 Stable Cell Line (HepG2-WT-ApoA1) serves as a robust in vitro model to study the normal physiological processes mediated by the wild-type Apolipoprotein A-I (ApoA-I), a key protein in lipid metabolism with antiatherogenic properties. This cell line mimics healthy liver cells’ conditions by maintaining typical ApoA-I expression and secretion levels. Researchers can use this model to investigate ApoA-I’s protective functions against cardiovascular diseases and its role in cholesterol metabolism and high-density lipoprotein (HDL) functionality. Additionally, this cell line is valuable for screening potential drugs targeting ApoA-I interactions and for studying its role in systemic amyloidosis when compared to mutant forms.Additional cell lines from this panel: Cat. T3532 – Mutant L75P-ApoA-I HepG2 Stable Cell Line (HepG2-L75P-ApoA1)
